母培强

发布者:生命科学学院发布时间:2018-08-09浏览次数:5422


        副研究员  性别: 男

        所属单位:生物化学系

 

        Email:mpeiqiang@scau.edu.cn

  


工作经历

1. 2018/01-今,华南农业大学,生命科学学院生化与分子生物学系,副研究员;

2. 2021/08-2022/10,Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Visiting Scholar;

3. 2015/05-今,华南农业大学,生命科学学院生化与分子生物学系,青年副教授;

4. 2014/07-2017/12,华南农业大学,生命科学学院生化与分子生物学系,助理研究员;

5. 2013/10-2014/3,Johns Hopkins University (USA), Department of Biology, Visiting Scholar

6. 2011/08-2014/06,华南农业大学,生命科学学院生化与分子生物学系,博士后。合作导师:邓诣群。


学习经历

学位学历学科门类专业毕业学校类型入学时间毕业时间
博士

博士

研究生

理学遗传学   中山大学 全日制2006-09 2011-07
学士大学本科 农学  蚕学华南农业大学 全日制2002-092006-07


研究兴趣

霉菌毒素的分子毒理与代谢转化:霉菌毒素诱导的异常细胞分裂机制、霉菌毒素生物降解等


主持科研项目

1.国家自然科学基金面上项目,32172770,双功能菌Slackia sp. D-G6在猪肠道中对呕吐毒素的协同解毒机制,2022/01-2025/12,在研,主持。

2. 广东省自然科学基金,2019A1515011519,基于细胞周期阻滞的呕吐毒素致猪肝毒性的分子机制研究,2019/10/-2022/10,已结题,主持;

3.广州市科技计划科学研究专项201607010257,临床分离的猪沙门氏菌多重耐药机制研究, 2016/04-2019/03,已结题,主持;

4. 国家自然科学基金青年基金,31402250,多重耐药猪沙门氏菌耐药机制及抑制剂研究, 2015/01-2017/01,已结题,主持;

5. 广东省自然科学基金博士启动项目, S2012040007589,DON毒素生物脱毒关键酶的筛选鉴定, 2012/10-2014/10,已结题,主持;

6. 中国博士后科学基金面上项目,2012M511577,鸡肠道中DON毒素脱环氧代谢微生物及关键酶的筛选鉴定, 2012/05-2014/05,已结题,主持。


代表性论文

[1] Anna Klucnika, Peiqiang Mu, Jan Jezek, Matthew McCormack, Ying Di, Charles R. Bradshaw, Hansong Ma; REC drives recombination to repair double-strand breaks in animal mtDNA. Journal of Cell Biology, 2023; 222 (1): e202201137. 

[2] Boyan Huang#, Peiqiang Mu#, Yan Yu, Wenya Zhu, Tianqing Jiang, Rong Deng, Gongkan Feng, Jikai Wen, Xiaofeng Zhu, Yiqun Deng. Inhibition of EZH2 and activation of ERRγ synergistically suppresses gastric cancer by inhibiting FOXM1 signaling pathway. Gastric Cancer, 2021. 24(1):72-84.

[3] Haibin Mu#, Peiqiang Mu#, Wenya Zhu, Boyan Huang, Hui Li, Liping Yuan, Yiqun Deng. Low doses of deoxynivalenol inhibit the cell migration mediated by H3K27me3-targeted downregulation of TEM8 expression. Biochemical Pharmacology, 2020. 175: 113897.

[4] Boyan Huang#, Qingmei Chen#, Lingling Wang, Xiaojuan Gao, Wenya Zhu, Peiqiang Mu*, Yiqun Deng*. Aflatoxin B1 induces neurotoxicity through reactive oxygen species generation, DNA damage, apoptosis, and s-phase cell cycle arrest. International Journal of Molecular Sciences. 2020; 21(18): E6517. 

[5] Xiaojuan Gao#, Peiqiang Mu#, Xunhua Zhu, Xiaoxuan Chen, Shulin Tang, Yuting Wu, Xiang Miao, Xiaohan Wang, Jikai Wen, Yiqun Deng. Dual function of a novel bacterium, Slackia sp. D-G6: detoxifying deoxynivalenol and producing the natural estrogen analogue, equol. Toxins, 2020. 12(2): 85.

[6] Boyan Huang#, Peiqiang Mu#, Xiaoxuan Chen, Shulin Tang, Wenchu Ye, Wenya Zhu, and Yiqun Deng, Aflatoxin B-1 induces S phase arrest by upregulating the expression of p21 via MYC, PLK1 and PLD1. Biochemical Pharmacology, 2019. 166: 108-119. 

[7] Xiaojuan Gao#, Peiqiang Mu#, Jikai Wen, Yu Sun, Qingmei Chen, and Yiqun Deng, Detoxification of trichothecene mycotoxins by a novel bacterium, Eggerthella sp DII-9. Food and Chemical Toxicology, 2018. 112: 310-319. 

[8] Peiqiang Mu, Ming Zheng, Ming Xu, Yuanming Zheng, Xianqing Tang, Yufan Wang, Kaixin Wu, Qingmei Chen, Lijuan Wang, and Yiqun Deng, N-Oxide Reduction of Quinoxaline-1,4-Dioxides Catalyzed by Porcine Aldehyde Oxidase SsAOX1. Drug Metabolism and Disposition, 2014. 42(4): 511-519. 

[9] Peiqiang Mu, Ming Xu, Lei Zhang, Kaixin Wu, Jun Wu, Jun Jiang, Qingmei Chen, Lijuan Wang, Xianqing Tang, and Yiqun Deng, Proteomic changes in chicken primary hepatocytes exposed to T-2 toxin are associated with oxidative stress and mitochondrial enhancement. Proteomics, 2013. 13(21): 3175-3188. 

[10] Peiqiang Mu, Dongru Feng, Jianbin Su, Yang Zhang, Jinran Dai, Honglei Jin, Bing Liu, Yanming He, Kangbiao Qi, Hongbin Wang, and Jinfa Wang, Cu2+ triggers reversible aggregation of a disordered His-rich dehydrin MpDhn12 from Musa paradisiaca. Journal of Biochemistry, 2011. 150(5): 491-499. 


发明专利

[1] 邓诣群、郑鸣、唐先青、母培强,一种具有重要药物代谢活性的猪醛氧化酶(SsAOX1)的基因序列及其应用,2015. 04.08,中国,ZL201210385945.0

[2] 邓诣群、高小娟、母培强、陈庆梅、文继开,一株高效降解呕吐毒素的伊格尔兹氏菌Eggerthella sp.D II-92017.07.11,中国,ZL 201610785205.4

[3] 邓诣群、母培强、高小娟、陈庆梅、文继开,伊格尔兹氏菌Eggerthella sp. DII -9在降解呕吐毒素中的应用,2018.03.06,中国,ZL201610785036.4

[4] 邓诣群、汪玲玲、蒋珺、吴骏、母培强、邓凤如,一株高效降解黄曲霉毒素B1的大肠杆菌CG10612020.08.07,中国,ZL201810317744.4

[5] 邓诣群、汪玲玲、蒋珺、吴骏、母培强、邓凤如,大肠杆菌在降解代谢黄曲霉毒素B1方面的应用,2020.08.07,中国,ZL201810316911.3

[6] 邓诣群高小娟母培强文继开祝勋花吴玉婷,一株史雷克氏菌及其在降解呕吐毒素中的应用,2021.05.25,中国,ZL201910493701.6


学术会议报告

1. Peiqiang Mu, The Dual role of mitochondrion in T-2 toxin response, 12th Conference of the Asian Society of Mitochondrial Research and Medicine (ASMRM) and The 6th Conference of Chinese Society of Mitochondrial Research and Medicine (Chinese-Mit), Hangzhou, China, 13 - 15 November 2014

2. 母培强,霉菌毒素T-2的毒性机理研究,动物生理生化学会第13次学术年会,20148月,沈阳,中国。