个人简介

蒋珺,女,博士,华南农业大学生命科学学院副研究员,硕士生导师。2009年毕业于中国科学院水生生物研究所,获遗传学博士学位。2009-2011年,在华南农业大学生化与分子生物学系从事博士后工作,期间分别获得博士后科学基金面上资助和特别资助,并以高级研究助理身份赴香港李嘉诚医学院解剖学系进修。在博士后研究期间,首次揭示猪CYP3A46能催化T-2毒素发生3’-羟化反应。目前,主要从事猪、鸡细胞色素P450氧化酶(特别是参与T-2毒素代谢的细胞色素P450氧化酶)的功能、结构及表达调控机制研究。在蛋白表达纯化、酶动力学分析、启动子活性检测等方面有着丰富的研究经验。累积发表SCI论文21篇,其中第一作者论文7篇,累积影响因子超80

工作经历

·           2009.9-2011.6,华南农业大学生命科学学院,生化与分子生物学专业,博士后

·           2011.5-2011.10,香港大学李嘉诚医学院,解剖学系,高级研究助理

·           2011.7至今,华南农业大学生命科学学院,生化与分子生物学专业,副研究员

 

学习经历
学位学历学科门类专业毕业学校类型入学时间毕业时间
博士博士研究生
理学
遗传学
中国科学院水生生物研究所
全日制 2004-092009-07
学士大学本科
理学
生物科学
华中师范大学
全日制 2000-092004-07
主持或参加的科研项目

1.       国家自然科学基金青年科学基金项目,No. 312017162013.1-2015.1221万,主持,在研

2.       高等学校博士学科点专项科研基金新教师类,No. 201244041200122013.1-2015.124万,主持,在研

3.       广东省自然科学基金博士启动项目,No. S20120400076672012.10-2014.103万,主持,在研

4.       中国博士后科学基金特别资助第4批,No. 2011043622011.4-2012.910万,主持,结题

5.       中国博士后科学基金面上资助第47批,No. 201004709302010.4-2011.93万,主持,结题

6.       国家重点基础研究发展计划(973计划)子课题,No. 2009CB1188022009.1-2013.8412万,参加(学术骨干),结题

 

发表论文

1.       Shirley M.H. Sy§, Jun Jiang§, Wai Sum O, Yiqun Deng, Michael S.Y. Huen. 2013. The Ubiquitin Specific Protease USP34 Promotes Ubiquitin Signaling at DNA Double-Strand Breaks. Nucleic Acids Research. 41(18): 8572-8580. (5-Yr IF: 8.055) (§co-first author)

2.       Hua Cai§, Jun Jiang§, Qi Yang, Qingmei Chen, Yiqun Deng. 2012. Functional Characterization of a First Avian Cytochrome P450 of the CYP2D Subfamily (CYP2D49). PLoS One. 7(6): e38395. (5-Yr IF: 4.244) (§co-first author)

3.       Jianshe Wang§, Jun Jiang§, Hongxia Zhang, Junping Wang, Hua Cai, Cheng Li, Kangbai Li, Jing Liu, Xuejiang Guo, Guangxun Zou, Dazhi Wang, Yiqun Deng, Jiayin Dai. 2011. Integrated transcriptional and proteomic analysis with in vitro biochemical assay reveal the important role of CYP3A46 in T-2 toxin hydroxylation in porcine primary hepatocytes. Molecular and Cellular Proteomics. 10(9): 10.1074/mcp.M111.008748, 1-18. (5-Yr IF: 8.051) (§co-first author)

4.       Shirley M.-H. Sy§, Jun Jiang§, Sui-sui Dong, Gabriel Tsz-Mei Lok, Jun Wu, Hua Cai, Enoch S.L. Yeung, Jun Huang, Junjie Chen, Yiqun Deng, Michael S.Y. Huen. 2011. Critical roles of ring finger protein RNF8 in replication stress responses. Journal of Biological Chemistry. 286(25): 22355-22361. (5-Yr IF: 5.023) (§co-first author)

5.       Jun Jiang, Junping Wang, Hua Cai, Kangbai Li, Yiqun Deng. 2011. CYP3As catalyze nifedipine oxidation in pig liver microsomes: enzyme kinetics, inhibition and functional expression. Catalysis Communications. 12(8): 694-697.  (5-Yr IF: 3.328)

6.       Jun Jiang, Yi-Bing Zhang, Shun Li, Fei-Fei Yu, Fan Sun, Jian-Fang Gui. 2009. Expression regulation and functional characterization of a novel interferon inducible gene Gig2 and its promoter. Molecular Immunology. 46(15): 3131-3140. (5-Yr IF: 2.917)

7.       Jian-Hong Xia§, Jun Jiang§, Yao-Hua Shi, Jian-Fang Gui. 2009. Predominant expression and cellular distribution of fish Agr2 in renal collecting system. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 152(4): 397-404. (5-Yr IF: 2.092) (§co-first author)

 

8.       Fan Sun, Yi-Bing Zhang, Jun Jiang, Bing Wang, Chen Chen, Jun Zhang, Jian-Fang Gui. 2014. Gig1, a novel antiviral effector involved in fish interferon response. Virology. 448: 322-332. (5-Yr IF: 3.164)

9.       Peiqiang Mu, Ming Xu, Lei Zhang, Kaixin Wu, Jun Wu, Jun Jiang, Qingmei Chen, Lijuan Wang, Xianqing Tang, Yiqun Deng. 2013. Proteomic changes in chicken primary hepatocytes exposed to T-2 toxin are associated with oxidative stress and mitochondrial enhancement. Proteomics. 13(21): 3175-3188. (5-Yr IF: 4.223)

10.    Shufeng Shang, Jun Jiang, Yiqun Deng. 2013. Chicken Cytochrome P450 1A5 is the Key Enzyme for Metabolizing T-2 Toxin to 3'OH-T-2. International Journal of Molecular Sciences. 14(6): 10809-10818. (5-Yr IF: 2.732)

11.    Yi-Bing Zhang, Ting-Kai Liu, Jun Jiang, Jun Shi, Ying Liu, Shun Li, Jian-Fang Gui. 2013. Identification of a novel Gig2 gene family specific to non-amniote vertebrates. PLoS One. 8(4): e60588. (5-Yr IF: 4.244)

12.    Jie Chen, Wanjuan Feng, Jun Jiang, Yiqun Deng, Michael S.Y. Huen. 2012. Ring Finger Protein RNF169 Antagonises the Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage. Journal of Biological Chemistry. 287(33): 27715-27722. (5-Yr IF: 5.023)

13.    Xianqing Tang, Peiqiang Mu, Jun Wu, Jun Jiang, Caihui Zhang, Ming Zheng, and Yiqun Deng. 2012. Carbonyl Reduction of Mequindox by Chicken and Porcine Cytosol and Cloned CBR1. Drug Metabolism and Disposition. 40(4): 788-795. (5-Yr IF: 3.678)

14.    Jing Liu, Man Ouyang, Jun Jiang, Peiqiang Mu, Jun Wu, Qi Yang, Caihui Zhang, Weiying Xu, Lijuan Wang, Michael S.Y. Huen, Yiqun Deng. 2012. Mequindox induced cellular DNA damage via generationof reactive oxygen species. Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 741(1-2): 70-75. (5-Yr IF: 2.843)

15.    Ming Zheng, Jun Jiang, Junping Wang, Xianqing Tang, Man Ouyang, Yiqun Deng. 2011. The Mechanism of Enzymatic and Non-enzymatic N-oxide Reductive Metabolism of Cyadox in Pig Liver. Xenobiotica. 41(11): 964–971. (5-Yr IF: 2.302)

16.    Jing Liu, Xiaohu Ge, Man Ouyang, Xianqing Tang, Jun Wu, Junping Wang, Jun Jiang, Michael S.Y. Huen, Yiqun Deng. 2011. Catalytic characteristics of CYP3A22-dependent mequindox detoxification. Catalysis Communications. 12(7): 637-643. (5-Yr IF: 3.382)

17.    Xiaohu Ge, Junping Wang, Jing Liu, Jun Jiang, Huina Lin, Jun Wu, Man Ouyang, Xianqing Tang, Ming Zheng, Ming Liao, Yiqun Deng. 2010. The catalytic activity of cytochrome P450 3A22 is critical for the metabolism of T-2 toxin in porcine reservoirs. Catalysis Communications. 12(2): 71-75. (5-Yr IF: 3.382)

18.    Fei-Fei Yu, Yi-Bing Zhang, Ting-Kai Liu, Ying Liu, Fan Sun, Jun Jiang, Jian-Fang Gui. 2010. Fish virus-induced interferon exerts antiviral function through Stat1 pathway. Molecular Immunology. 47(14): 2330-2341. (5-Yr IF: 2.917)

19.    Yan Shi, Yi-Bing Zhang, Zhe Zhao, Jun Jiang, Qi-Ya Zhang, Jian-Fang Gui. 2008. Molecular characterization and subcellular localization of Carassius auratus interferon regulatory factor-1. Developmental & Comparative Immunology. 32(2): 134-146. (5-Yr IF: 3.4)

20.    Yi-Bing Zhang, Jun Jiang, Yu-Dong Chen, Rong Zhu, Yan Shi, Qi-Ya Zhang, Jian-Fang Gui. 2007. The innate immune response to grass carp hemorrhagic virus (GCHV) in cultured Carassius auratus blastulae (CAB) cells. Developmental & Comparative Immunology. 31(3): 232-243. (5-Yr IF: 3.4)

21.    Yu-Dong Chen, Yi-Bing Zhang, Rong Zhu, Fu-Tie Zhang, Jun Jiang, Yan Shi, Qi-Ya Zhang, Song-Lin Chen, Jian-Fang Gui. 2005. Inductive expression and characterization analysis of Paralichthys olivaceus pigment epithelium-derived factor in a virally infected cell line. Biochemical and Biophysical Research Communications. 335(3): 799-809. (5-Yr IF: 2.5)