生命科学学院三十周年院庆系列学术报告之六:动脉粥样硬化的综合性治疗

发布者:生命科学学院发布时间:2012-10-15浏览次数:2149

报告时间:2012年10月16日(星期二)上午9:00


报告地点:红满堂报告厅


报 告 人:韩际宏 教授(南开大学生命科学学院,国家重点人才工程(国内)特聘教授)


主持人:生命科学学院院长 邓诣群教授


承办单位:宣传部、科技处、生命科学学院


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报告人简介:


    韩际宏,男,南开大学生命科学学院教授,973计划首席科学家,国家重点人才工程(国内)特聘教授。1995年毕业于美国康乃尔大学医学院(Center of Vascular Biology, Weill Medical College of Cornell University),获理学博士学位。研究领域为动脉粥样硬化成病机理与治疗;胆固醇及脂质代谢信号通路。在Immunity、circulation、Journal of Experimental Medicine、PNAS、JBC、Biomaterials、Journal of Experimental Medicine等国际杂志发表论文三十余篇。


    代表性论文:(*: 通讯作者)
1.Mårtensson J, Han J, Griffith OW, Meister A. 1993. Glutathione ester delays the onset of scurvy in ascorbate-deficient guinea pigs. Proceedings of the National Academy of Sciences, USA 90:317-21
2.Han J, Febbraio M, Hajjar DP, Nicholson AC. 1997. Native and modified low density lipoproteins increase the functional expression of macrophage class B scavenger receptor, CD36. The Journal of Biological Chemistry 272:21654-9
3.Han J, Nicholson AC. 1998. Lipoproteins modulate expression of the macrophage scavenger receptor. The American Journal of Pathology 152:1647-54
4.Han J, Hajjar DP, Tauras JM, Nicholson AC. 1999. Cellular cholesterol regulates the expression of macrophage scavenger type B receptor, CD36. Journal of Lipid Research 40:830-8
5.Han J, Hajjar DP, Tauras JM, Feng J, Gotto AM Jr, Nicholson AC. 2000. Transforming growth factor-1 (TGF-1) and TGF-2 decrease expression of CD36, the type B scavenger receptor, through mitogen-activated protein kinase phosphorylation of peroxisome proliferator-activated receptor-. The Journal of Biological Chemistry 275:1241-6
6.Han J, Feng J, Pearce SFA, Silverstein RL, Gotto AM Jr, Hajjar DP, Nicholson AC. 2000. Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR. Journal of Lipid Research 40:688-96
7.Han J, Nicholson AC, Zhou X, Feng J, Gotto AM Jr, Hajjar DP. 2001. Oxidized LDL decreases macrophage expression of scavenger receptor B-I (SR-BI). The Journal of Biological Chemistry 276:16567-72
8.Han J, Hajjar DP, Zhou X, Gotto AM Jr, Nicholson AC. 2002. Regulation of peroxisome proliferator-activated receptor--mediated gene expression. A new mechanism of action for high density lipoprotein. The Journal of Biological Chemistry 277:23582-6
9.Han J, Markle RA, Summers BD, Yokoyama T, Hajjar KA, Hajjar DP, Gotto AM Jr, Nicholson AC. 2003. Pitavastatin alters the expression of thrombotic and fibrinolytic proteins in human vascular cells. Journal of Cellular Biochemistry 90:23-32
10.Sun L, Nicholson AC, Hajjar DP, Gotto AM Jr, Han J*. 2003. Adipogenic differentiating agents regulate expression of fatty acid binding protein (aP2) and CD36 in macrophages. Journal of Lipid Research 44:1877-86
11.Han J, Zhou X, Hajjar DP, Gotto AM Jr, Nicholson AC. 2004. Pitavastatin down-regulates expression of the macrophage type B scavenger receptor, CD36. Circulation 109:790-6
12.Han J*, Parsons M, Zhou X, Nicholson AC, Gotto AM Jr, Hajjar DP. 2004. Functional interplay between the macrophage scavenger receptor class B type I (SR-BI) and pitavastatin (NK-104). Circulation 110:3472-9
13.Han J*, Zhou X, Parsons M, Nicholson AC, Gotto AM Jr, Yokoyama T, Hajjar DP. 2005. Regulation of macrophage scavenger receptor expression-New pleiotropic effects of statins. pp265-269. Advances in Heart Disease, International Academy of Cardiology. Asher Kimchi, Ed. International Proceeding
14.Nicholson AC, Zhou X, He W, Gotto AM Jr, Hajjar DP, Han J*. 2007. Anti-adipogenic action of pitavastatin occurs through the coordinate regulation of PPARand Pref-1 expression. British Journal of Pharmacology 151:807-15.
15.Zhou X, He W, Huang Z, Gotto AM Jr, Hajjar DP, Han J*. 2008. Genetic deletion of low density lipoprotein receptor impairs mouse macrophage ABCA1 expression-A SREBP-1 dependent mechanism. Journal of Biological Chemistry 283:2129-38
16.Huang Z, He W, Zhou X, Hajjar DP, Nicholson AC, Gotto AM Jr, Han J*. 2008. Activation of PPAR induces hepatic LDL receptor expression. British Journal of Pharmacology 155:596-605
17.Nakaya H, Summers BD, Nicholson AC, Gotto AM Jr, Hajjar DP, Han J*. 2009. Atherosclerosis in LDLR knockout mice is inhibited, but not reversed by the PPAR ligand pioglitazone. American Journal of Pathology. 174:2007-14
18.Zhou X, Yin Z, Guo X, Hajjar DP, Han J*. 2010. Inhibition of ERK1/2 and activation of LXR synergistically induce macrophage ABCA1 expression and cholesterol efflux. Journal of Biological Chemistry 285:6316-26
19.Dong P, Xie T, Zhou X, Hu W, Chen Y, Duan Y, Li X, Han J*. 2011. Induction of macrophage scavenger receptor type BI expression by tamoxifen and 4-hydroxytamoxifen. Atherosclerosis 218:435-42
20.Hu W, Zhou X, Jiang N, Duan Y, Chen Y, Li X, Yin Z, He G, Yao Z, Zhu Y, Hajjar DP, Han J*. 2012. Statins synergize dexamethasone-induced adipocyte fatty acid binding protein expression in macrophages. Atherosclerosis. 222:434-43
21.Duan Y, Chen Y, Hu W, Li X, Zhou X, Yin Z, Kong D, Hajjar DP, Liu L, Liu Q,  Han J*. 2012. PPAR activation by ligands and dephosphorylation induces PCSK9 and LDLR expression. The Journal of Biological Chemistry 287:23667-23677