李发强:教授    性别:男

  所属单位:植物学系

  Email:fqli@scau.edu.cn

  




工作

2015/10-present  Principle Investigator, College of Life Sciences, South China Agricultural University

2014/01-2015/09  Assistant Scientist, Department of Genetics, University of Wisconsin, Madison, USA

2009/01-2013/12  Research Associate, Department of Genetics, University of Wisconsin, Madison, USA


教育经历

2001/09-2008/02,美国纽约城市大学研究生院和大学中心(CUNY-Graduate School and University Center),

哲学博士,生物化学专业

1998/09-2001/07,中山大学生命科学学院,理学硕士,遗传专业

1994/09-1998/07,中山大学生命科学学院,理学学士,微生物学专业


研究领域

        Autophagy (“self-eating”) is a highly conserved degradation process in eukaryotes whereby organelles and cytoplasm are sequestered in vesicles, which are subsequently delivered to the vacuole for breakdown. Autophagy-mediated turnover plays an essential role in cellular housekeeping and is critical for plant defense and robust nutrient recycling. We are interested in elucidating the role of plant ATG (AuTophaGy-related) genes to understand its contribution to plant biology, which may offer us new strategies to improve the agronomic performances and yields of crops by altering this process.


科研项目

1. 国家自然基金面上项目,拟南芥ABA受体通过选择性细胞自噬降解的分子机制研究2020/01-2023/12,在研,主持。

2. 广东省自然科学基金项目,ATG8互作蛋白FYVE2a/b调控植物细胞自噬的分子机制研究,2018/05-2021/04

在研,参加

3. 国家自然基金面上项目,细胞自噬在玉米胚乳发育过程中的作用及调控机制的研究,2018/01-2021/12,在研,主持。

4. 农业大学丁人才重点培养目,2016始,在研,主持。

5. 农业大学高次引人才科研启动项目,2015/10始,在研,主持。


发表论文

1.Huang, X., Zheng, C., Liu, F., Yang, C., Zheng, P., Lu, X., Tian, J., Chung, T., Otegui, M.S., Xiao, S., Gao, C., Vierstra, R.D.*, and Li, F.* (2019). Genetic analyses of the Arabidopsis ATG1 kinase complex reveal both kinase-dependent and independent autophagic routes during fixed-carbon starvation. Plant Cell. (*Co-corresponding author, in press, DOI: https://doi.org/10.1105/tpc.19.00066)

2.Gou, W., Li, X., Guo, S., Liu, Y., Li, F., and Xie, Q.* (2019). Autophagy in plant: a new orchestrator in the regulation of the phytohormones homeostasis. Int. J. Mol. Sci. 20(12), 2900.

3.Liu, F., Marshall, R.S., and Li, F.* (2018). Understanding and exploiting the roles of autophagy in plants through multi-omics approaches. Plant Sci. 274, 146-152.

4.McLoughlin, F., Augustine, R.C., Marshall, R.S., Li, F., Kirkpatrick, L.D., Otegui, M.S., and Vierstra, R.D.* (2018). Maize multi-omics reveal roles for autophagic recycling in proteome remodelling and lipid turnover. Nat. Plants. 4, 1056-1070.

5.Qi, H., Xia, F.N., Xie, L.J., Yu, L.J., Chen, Q.F., Zhuang, X.H., Wang, Q., Li, F., Jiang, L., Xie, Q., and Xiao, S.* (2017). TRAF-family proteins regulate autophagy dynamics by modulating AUTOPHAGY PROTEIN6 stability in Arabidopsis. Plant Cell. 29:890-911.

6.Chen, L., Li, F.*, and Xiao, S.* (2017). Analysis of plant autophagy. Methods Mol. Biol. 1662, 267-280. (*Co-corresponding author)

7.黄晓, 李发强*. (2016). 细胞自噬在植物细胞程序性死亡中的作用. 植物学报. 51, 859-862.

8.Klionsky, D.J.*, and multiple authors including Li F., (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12, 1-222.

9.Li, F., Chung, T., Pennington, J.G., Federico, M.L., Kaeppler, H.F., Kaeppler, S.M., Otegui, M.S., and Vierstra, R.D.* (2015). Autophagic recycling plays a central role in maize nitrogen remobilization. Plant Cell. 27, 1389-1408.

10.Marshall, R.S., Li, F., Gemperline, D.C., Book, A.J., and Vierstra, R.D.* (2015). Autophagic degradation of the 26S proteasome is mediated by the dual ATG8/Ubiquitin receptor RPN10 in Arabidopsis. Mol. Cell. 58, 1053-1066.

11.Spitzer, C., Li, F., Buono, R., Roschzttardtz, H., Chung, T., Zhang, M., Osteryoung, K.W., Vierstra, R.D., and Otegui, M.S.* (2015). The endosomal protein CHARGED MULTIVESICULAR BODY PROTEIN1 regulates the autophagic turnover of plastids in Arabidopsis. Plant Cell. 27:391-402

12.Li, F., Chung, T., and Vierstra, R.D.* (2014). AUTOPHAGY-RELATED11 plays a critical role in general autophagy- and senescence-induced mitophagy in Arabidopsis. Plant Cell. 26, 788-807.

13.Li, F., and Vierstra, R.D.* (2014). Arabidopsis ATG11, a scaffold that links the ATG1-ATG13 kinase complex to general autophagy and selective mitophagy. Autophagy. 10, 1466-1467.

14.Klionsky, D.J.*, and multiple authors including Li F., (2012). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8, 445-544.

15.Li, F., and Vierstra, R.D.* (2012a). Autophagy: a multifaceted intracellular system for bulk and selective recycling. Trends Plant Sci. 17, 526-537.

16.Li, F., and Vierstra, R.D.* (2012b). Regulator and substrate: dual roles for the ATG1-ATG13 kinase complex during autophagic recycling in Arabidopsis. Autophagy.8, 982-984.

17.Suttangkakul, A., Li, F.#, Chung, T., and Vierstra, R.D.* (2011). The ATG1/ATG13 protein kinase complex is both a regulator and a target of autophagic recycling in Arabidopsis. Plant Cell. 23, 3761-3779. (#Co-first author)

18.Chen, Y., Li, F.#, and Wurtzel, E.T.* (2010). Isolation and characterization of the Z-ISO gene encoding a missing component of carotenoid biosynthesis in plants. Plant Physiol. 153, 66-79. (#Co-first author)

19.Li, F., Tsfadia, O., and Wurtzel, E.T.* (2009). The phytoene synthase gene family in the Grasses: subfunctionalization provides tissue-specific control of carotenogenesis. Plant Signal Behav. 4, 208-211.

20.Li, F., Vallabhaneni, R., Yu, J., Rocheford, T., and Wurtzel, E.T.* (2008b). The maize phytoene synthase gene family: overlapping roles for carotenogenesis in endosperm, photomorphogenesis, and thermal stress tolerance. Plant Physiol. 147, 1334-1346.

21.Li, F., Vallabhaneni, R., and Wurtzel, E.T.* (2008a). PSY3, a new member of the phytoene synthase gene family conserved in the Poaceae and regulator of abiotic stress-induced root carotenogenesis. Plant Physiol. 146, 1333-1345.

22.Li, F., Murillo, C., and Wurtzel, E.T.* (2007). Maize Y9 encodes a product essential for 15-cis-zeta-carotene isomerization. Plant Physiol. 144, 1181-1189.

23.Gallagher, C.E., Matthews, P.D., Li, F., and Wurtzel, E.T.* (2004). Gene duplication in the carotenoid biosynthetic pathway preceded evolution of the grasses. Plant Physiol. 135, 1776-1783.


教学活动

承担《分子生物化学(双语)》、《细胞生物学(双语)》等本科课程及硕士生《蛋白质翻译后修饰》的教学工作。