蒋珺

发布者:生命科学学院发布时间:2018-08-09浏览次数:4480


      副研究员、硕士生导师  性别:女

      所属单位:生物化学系

      Email:jiangjun@scau.edu.cn


  



学习经历  

1. 2004/09-2009/07,中国科学院水生生物研究所,博士,导师:桂建芳院士

2. 2000/09-2004/07,华中师范大学,生命科学学院,学士 


工作经历

1.2019/09-2020/09,美国加州大学欧文分校,访问学者

2.2011/07-至今,华南农业大学,生命科学学院,副研究员

3.2011/04-2011/10,香港大学,李嘉诚医学院,高级研究助理

4.2009/07-2011/07,华南农业大学,生命科学学院,博士后,合作导师:邓诣群教授 


研究方向

1. 畜禽霉菌毒素中毒病的发生发展机制与防控

2. 参与霉菌毒素代谢关键酶的功能、结构与调控


代表论文

1.Jun Jiang#, Jiahui Zhu#, Qian Liu#, Tingting Zhang, Jikai Wen, Yiqun Deng*. Role of DNA methylation-related chromatin remodeling in aryl hydrocarbon receptor-dependent regulation of T-2 toxin highly inducible Cytochrome P450 1A4 gene. The FASEB Journal. 2021; 35: e21469.

2.Qian Liu, Jikai Wen, Jiahui Zhu, Tingting Zhang, Yiqun Deng*, Jun Jiang*. Aromatic Hydrocarbon Receptor Regulates Chicken Cytochrome P450 1A5 Transcription: A Novel Insight into T-2 Toxin-induced Gene Expression and Cytotoxicity in LMH Cells. Biochemical Pharmacology. 2019 Oct; 168: 319-329.

2.Haoran Jiang, Jun Wu, Feiyong Zhang, Jikai Wen, Jun Jiang*, Yiqun Deng*. The critical role of porcine cytochrome P450 3A46 in the bioactivation of aflatoxin B1. Biochemical Pharmacology. 2018 Oct; 156: 177-185. 

3.Jun Jiang#, Shulin Tang#, Jianhong Xia, Jikai Wen, Shuang Chen, Xiaodong Shu, Michael S. Y. Huen, Yiqun Deng*. C9orf140, a novel Axin1-interacting protein, mediates the negative feedback loop of Wnt/β-catenin signaling. Oncogene. 2018 May; 37: 2992-3005.  

4.Linfeng Dong, Qingmei Chen, Xin Liu, Jikai Wen, Jun Jiang*, Yiqun Deng*. Role of Specificity Protein 1, Hepatocyte Nuclear Factor 1α, and Pregnane X Receptor in the Basal and Rifampicin-Induced Transcriptional Regulation of Porcine Cytochrome P450 3A46. Drug Metabolism and Disposition. 2015 Oct; 43(10): 1458-1467. 

5.Qi Yang, Shulin Tang, Linfeng Dong, Qingmei Chen, Xin Liu, Jun Jiang*, Yiqun Deng*. Transcriptional regulation of chicken cytochrome P450 2D49 basal expression by CCAAT/enhancer-binding protein α and hepatocyte nuclear factor 4α. FEBS Journal. 2014 Mar; 281(5): 1379-1392.  

6.Shirley M.H. Sy#, Jun Jiang#, Wai Sum O, Yiqun Deng*, Michael S.Y. Huen*. The Ubiquitin Specific Protease USP34 Promotes Ubiquitin Signaling at DNA Double-Strand Breaks. Nucleic Acids Research. 2013 Oct; 41(18): 8572-8580.

7.Hua Cai#, Jun Jiang#, Qi Yang, Qingmei Chen, Yiqun Deng*. Functional Characterization of a First Avian Cytochrome P450 of the CYP2D Subfamily (CYP2D49). PLoS One. 2012 Jun 4; 7(6): e38395. 

8.Jianshe Wang#, Jun Jiang#, Hongxia Zhang, Junping Wang, Hua Cai, Cheng Li, Kangbai Li, Jing Liu, Xuejiang Guo, Guangxun Zou, Dazhi Wang, Yiqun Deng*, Jiayin Dai*. Integrated transcriptional and proteomic analysis with in vitro biochemical assay reveal the important role of CYP3A46 in T-2 toxin hydroxylation in porcine primary hepatocytes. Molecular & Cellular Proteomics. 2011 Sep; 10(9): M111.008748, 1-18.  

9.Shirley M.-H. Sy#, Jun Jiang#, Sui-sui Dong, Gabriel Tsz-Mei Lok, Jun Wu, Hua Cai, Enoch S.L. Yeung, Jun Huang, Junjie Chen, Yiqun Deng*, Michael S.Y. Huen*. Critical roles of ring finger protein RNF8 in replication stress responses. Journal of Biological Chemistry. 2011 Jun 24; 286(25): 22355-22361.

10.Jun Jiang#, Junping Wang#, Hua Cai, Kangbai Li, Yiqun Deng*. CYP3As catalyze nifedipine oxidation in pig liver microsomes: enzyme kinetics, inhibition and functional expression. Catalysis Communications. 2011 Mar 31; 12(8): 694-697. 


主持与参加的科研项目

1. 广东省自然科学基金面上项目,2021主持

2. 国家自然科学基金联合基金重点项目,2020,参与

3.广东省自然科学基金面上项目,2018,主持

4.广东省自然科学基金研究团队,2015,核心成员

5.国家自然科学基金青年科学基金项目,2013,主持

6.高等学校博士学科点专项科研基金新教师类,2013,主持

7.中国博士后科学基金特别资助,2011,主持

8.国家重点基础研究发展计划(973计划)子课题,2009,参加


入选的人才基金项目

1.广州市科技计划项目珠江科技新星专项,2016

2.广东省高等学校优秀青年教师培养计划,2015

3.广东省高等学校“千百十人才培养工程”第八批校级培养对象,2014


授权发明专利  

1.邓诣群;汪玲玲;蒋珺;吴骏;母培强;邓凤如;大肠杆菌在降解代谢黄曲霉毒素B1方面的应用,2020-08-07,中国,ZL201810316911.3.

2.邓诣群;汪玲玲;蒋珺;吴骏;母培强;邓凤如;一株高效降解黄曲霉毒素B1的大肠杆菌CG1061,2020-08-07,中国,ZL201810317744.4.


学术兼职

1.中国生物化学与分子生物学会农业分会 青年委员会委员

2.广东省生物化学与分子生物学学会  理事

3.广东省药理学会药物代谢专业委员会 委员