陈远玲:副研究员  性别:女

  所属单位:生物化学与分子生物学系

  Email:pcb2000@scau.edu.cn

  



个人简介

     博士,副研究员,硕士生导师。长期专注于植物的遗传与发育分子机理研究,重点探究水稻株型与生殖发育的遗传与分子机理。克隆了水稻Ptd1基因并阐明了其光温敏控制株高的分子机制,发现定点改变参与蛋白构象形成的保守氨基酸可赋予蛋白新的生物学功能。参与课题组基因编辑、突变体库创建等技术平台的开发,创立了一种EMS诱变悬浮细胞建立突变体库的高效方法,获得的突变体无嵌合体,特别适用于大规模建库以发掘新基因或新调控位点及筛选通路的上游基因。热爱教学,注重培养学生独立思考精神和创新能力。讲授课程: 遗传学 (本科生专业核心课,2005年至今);Cell Biology and Genetics (for China-Ireland joint class2018-2019)

工作经历

      2007.12-至今:华南农业大学生命科学学院,副研究员

2016.3-2017.3:美国克莱姆森大学(Clemson University),遗传与生化系,访问学者

2005.4-2005.8:香港大学植物学系,研究助理

1996.3-2007.11:华南农业大学生物技术学院/生命科学学院 (2001.7更名),助理研究员

1995.7-1996.2:华南农业大学实验中心,助理研究员

1992.7-1995.6:华南农业大学实验中心,研究实习员

主要研究领域

水稻株型与生殖发育的遗传与分子机理

主持的科研课题

1. 利用CRISPR/Cas9系统创制籼粳杂交亲和的条件可控雄性不育系
  农业部转基因生物新品种培育重大专项 (2016ZX08010-001,2016.1-2018.12)。子课题负责人。
2. 建立基于CRISPR/Cas9的植物基因组靶向技术体系
  农业部转基因生物新品种培育重大专项(2014ZX08010-001,2014.1-2015.12)。任务负责人。
3. 控制水稻株高的脂质转移蛋白基因的克隆与分子机理研究
   国家自然科学基金资助项目(31271301,2013.1-2016.12)。主持人。
4. 快速有效生成TALENs重复可变区技术体系的建立
  农业部转基因生物新品种培育重大专项(2013ZX08010-001,2013.1-2013.12)。任务负责人。
5. 水稻产量、育性等性状功能基因组
  国家863课题(2012AA10A303,2012.1-2015.12)。任务负责人。
6. 高效的基因转化技术系统构建
  农业部转基因生物新品种培育重大专项(2011ZX08010-001,2011.7-2012.12)。任务负责人。
7. 水稻衰老相关基因的克隆
  转基因生物新品种培育科技重大专项(2008ZX08009-003,2008.7-2010.12)。任务负责人。
8. 水稻雌配子体发育相关基因的分离与功能分析
  国家自然科学基金资助项目(30570969,2006.1-2008.12)。主持人。

发表的主要研究论文

1.Deng W#, Li R#, Xu Y#, Mao R#, Chen S, Chen L, Chen L, Liu YG*, Chen Y*. 2020. A lipid transfer protein variant with a mutant eight-cysteine motif causes photoperiod- and thermo-sensitive dwarfism in rice. J Exp Bot. 71(4):1294-1305. doi: 10.1093/jxb/erz500. (IF 2018= 5.360,共同通讯作者)

2.Hao Y#, Zong W#, Zeng D, Han J, Chen S, Tang J, Zhao Z, Li X, Ma K, Xie X, Zhu Q, Chen Y, Zhao X, Guo J*, Liu YG*. 2020. Shortened snRNA promoters for efficient CRISPR/Cas-based multiplex genome editing in monocot plants. Sci China Life Sci. doi: 10.1007/s11427-019-1612-6. (IF 2018= 3.583)

3.Li G, Liu YG*, Chen Y*. 2019. Genome-editing technologies: the gap between application and policy. Sci China Life Sci. 62(11):1534-1538. doi: 10.1007/s11427-019-1566-1. IF 2018= 3.583,共同通讯作者)

4.Wen L, Chen Y, Schnabel E, Crook A, Frugoli J*. 2019. Comparison of efficiency and time to regeneration of Agrobacterium-mediated transformation methods in Medicago truncatula. Plant Methods. 15:20, doi.org/10.1186/s13007-019-0404-1. IF 2018= 3.17

5.Xie Y#Zhang Y#Han JLuo JLi GHuang JWu HTian QZhu QChen YKawano YLiu Y-GChen L*. 2018. The intronic cis-element SE1 recruits trans-acting repressor complexes to repress the expression of ELONGATED UPPERMOST INTERNODE1 in rice. Mol Plant. 11(5):720-735IF 2017= 9.326

6.Zhu Q, Yu S, Zeng D, Liu H, Wang H, Yang Z, Xie X, Shen R, Tan J, Li H, Zhao X, Zhang Q, Chen Y, Guo J, Chen L and Liu Y-G*. 2017. Development of ‘‘Purple Endosperm Rice’’ by Engineering Anthocyanin Biosynthesis in the Endosperm with a High-Efficiency Transgene Stacking System. Mol Plant. 10(7):918-929. IF2017= 9.326

7.Lou S#, Chen S#, Zhao X, Chen L, Zhang J, Fu H, Liu YG*, Chen Y*. 2017. The far-upstream regulatory region of RFL is required for its precise spatial-temporal expression for floral development in rice. Plant Mol Biol. 93(1-2):185-195. (IF2017=3.543,共同通讯作者)

8.Li R#, Xia J#, Xu Y, Zhao X, Liu YG*, Chen Y*. 2014. Characterization and genetic mapping of a photoperiodsensitive dwarf 1 locus in rice (Oryza sativa L.) Theor Appl Genet. 127(1):241-250. IF2014=3.790,共同通讯作者)

9.Chen YL, Liang HL, Ma XL, Lou SL, Xie YY, Liu ZL, Chen L, Liu Y-G*. 2013. An Efficient Rice Mutagenesis System Based on Suspension-Cultured Cells. J Integr Plant Biol. 55:122-130. IF2013=3.448

10.Chen Y-L, Zhang Q-Y, Jian Y-Y, Yang Y-S, Liu K-D, Liu Y-G*. 2006. A rice panicle mutant created by transformation with an antisense cDNA library. J Integr Plant Biol. 48(11): 1300-1305. IF2006=0.515

11. Zhou L, Han J, Chen Y, Wang Y,* and Liu Y-G *. 2017. Bivalent Formation 1, a plant-conserved gene, encodes an OmpH/coiled-coil motif-containing protein required for meiotic recombination in rice. J Exp Bot.68(9):2163-2174. (IF2017= 5.354)

12. Ma X, Zhu Q, Chen Y, Liu Y-G*. 2016. CRISPR/Cas9 Platforms for Genome Editing in Plants: Developments and Applications. Mol Plant. 9(7):961-974. IF2016= 8.827

13. Tang H, Zheng X, Li C, Xie X, Chen Y, Chen L, Zhao X, Zheng H, Zhou J, Ye S, Guo J*, Liu Y-G*. 2017. Multi-step formation, evolution, and functionalization of new cytoplasmic male sterility genes in the plant mitochondrial genomes. Cell Research 27(1):130-146. (IF2017 = 15.393)

14. Ma X, Zhang Q, Zhu Q, Liu W, Chen Y, Qiu R, Wang B, Yang Z, Li H, Lin Y, Xie Y, Shen R, Chen S, Wang Z, Chen Y, Guo J, Chen L, Zhao X, Dong Z, Liu Y-G.* 2015. A robust CRISPR/Cas9 system for convenient, high-efficiency multiplex genome editing in monocot and dicot plants. Mol Plant. 8(8):1274-1284. (IF2015= 7.142)

15. Ma X, Chen L, Zhu Q, Chen Y, Liu Y-G*. 2015. Rapid decoding of sequence-specific nuclease-induced heterozygous and biallelic mutations by direct sequencing of PCR products. Mol Plant. 8(8):1285-1287. (IF2015=7.142)

16. Wu HB, Wang B, Chen Y, Liu YG*, Chen L*. 2013. Characterization and    fine-mapping of the rice premature senescence mutant ospse1. Theor Appl Genet. 126:1897-1907. (IF2013= 3.507)

17. Luo D, Xu H, Liu Z, Guo J, Li H, Chen L, Fang C, Zhang Q, Bai M, Yao N, Wu H, Wu H, Ji C, Zheng H, Chen Y, Ye S, Li X, Zhao X, Li R & Liu YG*. 2013. A Detrimental Mitochondrial-Nuclear Interaction Causes Cytoplasmic Male Sterility in Rice. Nat Genet. 45:573-577. (IF2013= 29.648)

18. Ji C, Li H, Chen L, Xie M, Wang F, Chen Y, Liu YG*. 2013. A novel rice bHLH transcription factor, DTD, acts coordinately with TDR in controlling tapetum function and pollen development. Mol Plant. 6(5):1715-1718. (IF2013= 6.605)

19.Long Y, Zhao L, Niu B, Su J, Wu H, Chen Y, Zhang Q, Guo J, Zhuang C, Mei M, Xia J, Wang L, Wu H, Liu Y-G. 2008. Hybrid male sterility in rice controlled by interaction between divergent alleles of two adjacent genes. Proc Natl Acad Sci USA. 105(48):18871-18876. (IF2008= 9.38)

20. Liu Y-G* and Chen Y. 2007. High-efficiency thermal asymmetric interlaced PCR for amplification of unknown flanking sequences. BioTechniques. 43(5): 649-656. (IF2007= 2.759)

21. Wang Z, Zou Y, Li X, Zhang Q, Chen L, Wu H, Su D, Chen Y, Guo J, Luo D, Long Y, Zhong Y, Liu Y-G*. 2006. Cytoplasmic male sterility of rice with boro II cytoplasm is caused by a cytotoxic peptide and is restored by two related PPR motif genes via distinct modes of mRNA silencing. Plant Cell, 18(3): 676-687. (IF2006=9.868)

22. Shih C-H, Chen Y, Wang M, Chu I K, Lo C*. 2008. Accumulation of isoflavone genistin in transgenic tomato plants overexpressing a soybean isoflavone synthase gene. J Agr Food Chem. 56(14):5655-5661. (IF2008=2.562)

23. Liu YG*, Chen Y, Zhang Q. 2005. Amplification of genomic sequences flanking T-DNA insertions by thermal asymmetric interlaced polymerase chain reaction. Methods in Molecular Biology. 286:341-348. (Transgenic plants: methods and protocols. Edited by L. Peña. Humana Press Inc., Totowa, NJ) 书中章节

24. Yang YJian YChen Y. 2000. Comparison of culture procedures for regeneration of plants from protoplast-derived calluses of rice (Oryza sativa L). Acta Agronomica Sinica. 26(4):490-495.

25. Yang Y-S, Zheng Y-D, Chen Y-L, Jian Y-Y. 1999. Improvement of plant regeneration from long-term cultured calluses of Taipei309, a model rice variety in in vitro studies. Plant Cell, Tissue and Organ Culture. 57(3):199-206.

26. 王裕霞,曾庆圣,陈远玲,罗建群,陈凤如. 2007. 丛生观赏竹组培微繁殖与诱变的初步研究. 竹子研究汇刊. 26(4):11-16.

27. 陈远玲,庄楚雄,李静,姜大刚. 2006. 研究性、开放性教学与团队学习. 高等农业教育.11: 37-39.

28. 陈远玲,张群宇,简玉瑜,杨跃生,刘耀光. 2004. 利用反义基因沉默策略构建水稻突变体库及突变体筛选. 华南农业大学学报 25(4):53-57.

29. 简玉瑜,陈远玲,李静,高丽丽,董春. 2001. 转基因水稻外源基因的遗传和表达初步研究. 华南农业大学学报. 22(1):56-59.

30. 陈远玲,简玉瑜,徐雪宾. 籼稻体细胞胚胎发生形态鉴别的研究. 1994. 华南农业大学学报. 15(1):78-84.

荣誉和奖励

1. 2017年,大北农科技奖,基因工程奖(独享),高效的植物基因组编辑载体系统和软件工具包及其应用(获奖人:刘耀光,马兴亮,谢先荣,陈乐天,张群宇,祝钦泷,郭晶心,陈远玲,沈荣鑫,谢勇尧,唐辉武,赵秀彩)

2. 2011年,广东省科学技术奖,一等奖,杂交稻育性遗传控制的分子机理研究(获奖人:刘耀光,王中华,龙云铭,邹艳姣,张群宇,赵利锋,李晓瑜,郭晶心,陈远玲,陈乐天,杨存义,刘振兰,庄楚雄,张桂权,梅曼彤)

发明专利

 一种调控水稻植株株高的方法。ZL201510840714.8(发明人:陈远玲,李日清,徐毅炜,陈水福,夏继星,刘耀光,陈乐天,毛润媛,刘鹏)