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工作经历
2015/10-present Principle Investigator, College of Life Sciences, South China Agricultural University
2014/01-2015/09 Assistant Scientist, Department of Genetics, University of Wisconsin, Madison, USA
2009/01-2013/12 Research Associate, Department of Genetics, University of Wisconsin, Madison, USA
教育经历
2001/09-2008/02，美国纽约城市大学研究生院和大学中心（CUNY-Graduate School and University Center），
哲学博士，生物化学专业
1998/09-2001/07，中山大学生命科学学院，理学硕士，遗传学专业
1994/09-1998/07，中山大学生命科学学院，理学学士，微生物学专业
研究领域
Autophagy (“self-eating”) is a highly conserved degradation process in eukaryotes whereby organelles and cytoplasm are sequestered in vesicles, which are subsequently delivered to the vacuole for breakdown. Autophagy-mediated turnover plays an essential role in cellular housekeeping and is critical for plant defense and robust nutrient recycling. We are interested in elucidating the role of plant ATG (AuTophaGy-related) genes to understand its contribution to plant biology, which may offer us new strategies to improve the agronomic performances and yields of crops by altering this process.
科研项目
1. 国家自然科学基金面上项目，拟南芥ABA受体通过选择性细胞自噬降解的分子机制研究，2020/01-2023/12，在研，主持。
2. 广东省自然科学基金项目，ATG8互作蛋白FYVE2a/b调控植物细胞自噬的分子机制研究，2018/05-2021/04，
在研，参加。
3. 国家自然科学基金面上项目，细胞自噬在玉米胚乳发育过程中的作用及调控机制的研究，2018/01-2021/12，在研，主持。
4. 华南农业大学丁颖人才重点培养对象项目，2016始，在研，主持。
5. 华南农业大学高层次引进人才科研启动项目，2015/10始，在研，主持。
发表论文
1.Huang, X., Zheng, C., Liu, F., Yang, C., Zheng, P., Lu, X., Tian, J., Chung, T., Otegui, M.S., Xiao, S., Gao, C., Vierstra, R.D.*, and Li, F.* (2019). Genetic analyses of the Arabidopsis ATG1 kinase complex reveal both kinase-dependent and independent autophagic routes during fixed-carbon starvation. Plant Cell. (*Co-corresponding author, in press, DOI: https://doi.org/10.1105/tpc.19.00066)
2.Gou, W., Li, X., Guo, S., Liu, Y., Li, F., and Xie, Q.* (2019). Autophagy in plant: a new orchestrator in the regulation of the phytohormones homeostasis. Int. J. Mol. Sci. 20(12), 2900.
3.Liu, F., Marshall, R.S., and Li, F.* (2018). Understanding and exploiting the roles of autophagy in plants through multi-omics approaches. Plant Sci. 274, 146-152.
4.McLoughlin, F., Augustine, R.C., Marshall, R.S., Li, F., Kirkpatrick, L.D., Otegui, M.S., and Vierstra, R.D.* (2018). Maize multi-omics reveal roles for autophagic recycling in proteome remodelling and lipid turnover. Nat. Plants. 4, 1056-1070.
5.Qi, H., Xia, F.N., Xie, L.J., Yu, L.J., Chen, Q.F., Zhuang, X.H., Wang, Q., Li, F., Jiang, L., Xie, Q., and Xiao, S.* (2017). TRAF-family proteins regulate autophagy dynamics by modulating AUTOPHAGY PROTEIN6 stability in Arabidopsis. Plant Cell. 29:890-911.
6.Chen, L., Li, F.*, and Xiao, S.* (2017). Analysis of plant autophagy. Methods Mol. Biol. 1662, 267-280. (*Co-corresponding author)
7.黄晓, 李发强*. (2016). 细胞自噬在植物细胞程序性死亡中的作用. 植物学报. 51, 859-862.
8.Klionsky, D.J.*, and multiple authors including Li F., (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12, 1-222.
9.Li, F., Chung, T., Pennington, J.G., Federico, M.L., Kaeppler, H.F., Kaeppler, S.M., Otegui, M.S., and Vierstra, R.D.* (2015). Autophagic recycling plays a central role in maize nitrogen remobilization. Plant Cell. 27, 1389-1408.
10.Marshall, R.S., Li, F., Gemperline, D.C., Book, A.J., and Vierstra, R.D.* (2015). Autophagic degradation of the 26S proteasome is mediated by the dual ATG8/Ubiquitin receptor RPN10 in Arabidopsis. Mol. Cell. 58, 1053-1066.
11.Spitzer, C., Li, F., Buono, R., Roschzttardtz, H., Chung, T., Zhang, M., Osteryoung, K.W., Vierstra, R.D., and Otegui, M.S.* (2015). The endosomal protein CHARGED MULTIVESICULAR BODY PROTEIN1 regulates the autophagic turnover of plastids in Arabidopsis. Plant Cell. 27:391-402
12.Li, F., Chung, T., and Vierstra, R.D.* (2014). AUTOPHAGY-RELATED11 plays a critical role in general autophagy- and senescence-induced mitophagy in Arabidopsis. Plant Cell. 26, 788-807.
13.Li, F., and Vierstra, R.D.* (2014). Arabidopsis ATG11, a scaffold that links the ATG1-ATG13 kinase complex to general autophagy and selective mitophagy. Autophagy. 10, 1466-1467.
14.Klionsky, D.J.*, and multiple authors including Li F., (2012). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8, 445-544.
15.Li, F., and Vierstra, R.D.* (2012a). Autophagy: a multifaceted intracellular system for bulk and selective recycling. Trends Plant Sci. 17, 526-537.
16.Li, F., and Vierstra, R.D.* (2012b). Regulator and substrate: dual roles for the ATG1-ATG13 kinase complex during autophagic recycling in Arabidopsis. Autophagy.8, 982-984.
17.Suttangkakul, A., Li, F.#, Chung, T., and Vierstra, R.D.* (2011). The ATG1/ATG13 protein kinase complex is both a regulator and a target of autophagic recycling in Arabidopsis. Plant Cell. 23, 3761-3779. (#Co-first author)
18.Chen, Y., Li, F.#, and Wurtzel, E.T.* (2010). Isolation and characterization of the Z-ISO gene encoding a missing component of carotenoid biosynthesis in plants. Plant Physiol. 153, 66-79. (#Co-first author)
19.Li, F., Tsfadia, O., and Wurtzel, E.T.* (2009). The phytoene synthase gene family in the Grasses: subfunctionalization provides tissue-specific control of carotenogenesis. Plant Signal Behav. 4, 208-211.
20.Li, F., Vallabhaneni, R., Yu, J., Rocheford, T., and Wurtzel, E.T.* (2008b). The maize phytoene synthase gene family: overlapping roles for carotenogenesis in endosperm, photomorphogenesis, and thermal stress tolerance. Plant Physiol. 147, 1334-1346.
21.Li, F., Vallabhaneni, R., and Wurtzel, E.T.* (2008a). PSY3, a new member of the phytoene synthase gene family conserved in the Poaceae and regulator of abiotic stress-induced root carotenogenesis. Plant Physiol. 146, 1333-1345.
22.Li, F., Murillo, C., and Wurtzel, E.T.* (2007). Maize Y9 encodes a product essential for 15-cis-zeta-carotene isomerization. Plant Physiol. 144, 1181-1189.
23.Gallagher, C.E., Matthews, P.D., Li, F., and Wurtzel, E.T.* (2004). Gene duplication in the carotenoid biosynthetic pathway preceded evolution of the grasses. Plant Physiol. 135, 1776-1783.
教学活动
承担《分子生物化学（双语）》、《细胞生物学（双语）》等本科课程及硕士生《蛋白质翻译后修饰》的教学工作。
