STAFF

Assoc.Prof. Jun Wu

Collegeof Life Sciences,
South China Agricultural University,

Guangzhou,Guangdong 510642, China
Tel: +86-20-38604967(O)
E-mail: wujun@scau.edu.cn


Education

  • Ph.D.(Biochemistry and Molecular Biology)

WuhanUniversity, China, 2006

  • B.S.(Material Science)

WuhanScience and Technology University, China, 2001


ProfessionalBiography

Dr.Jun Wu is focuses on using comprehensive methods involving incalculation biology, biochemistry, biophysics and molecular biologyto study the interactions between enzyme and substrate.


Areaof Expertise

Proteinengineering; Enzymology; Enzyme-substrate interactions; MolecularDocking


SelectedPublications

  1. JunWu1,Sisi Zhu1,Yunbo Wu, Tianqing Jiang, Lingling Wang, Jun Jiang, Jikai Wen,and Yiqun Deng*.Multiple CH/π interactions maintain the binding of aflatoxin B1in active cavity of human cytochrome P450 1A2. Toxins,2019, 11(3): 158-170.

  2. SisiZhu1,JunWu1,Silin Liu, Tianqing Jiang, Yiqun Deng*.Phe-125 and Phe-226 of pig cytochrome P450 1A2 stabilize thebinding of aflatoxin B1and 7-ethoxyresorufin through the key CH/π interactions.BiochemicalPharmacology,2019, 166(9):292-299. (co-first author)

  3. LinglingWang1,JunWu1,Zhiwen Liu, Yutao Shi, Jinqiu Liu, Xiaofan Xu, Shuxian Hao,Peiqiang Mu, Fengru Deng, and Yiqun Deng*,Aflatoxin B1 Degradation and Detoxification by Escherichia coliCG1061 Isolated From Chicken Cecum. Frontiersin Pharmacology,2019, 9:1548. doi: 10.3389/fphar.2018.01548. (co-first author)

  4. JunWu1,Ruohong Chen1,Caihui Zhang, Kangbai Li, Weiying Xu, Lijuan Wang, Qingmei Chen,Peiqiang Mu, Jun Jiang, JikaiWen and Yiqun Deng*.Bioactivation and regioselectivity of pig cytochrome P450 3A29towards aflatoxin B1. Toxins,2016, 8(9): 267-283.

  5. JunWu1,Weiying Xu1,Caihui Zhang, Qing Chang, Xianqing Tang, Kangbai Li, Yiqun Deng*.Trp266 determines the binding specificity of a porcine aflatoxinB1aldehyde reductase for aflatoxin B1-dialdehyde.BiochemicalPharmacology,2013, 86(9):1357-1365.

  6. HaoranJiang, JunWu,Feiyong Zhang, Jikai Wen, Jun Jiang, and Yiqun Deng, The criticalrole of porcine cytochrome P450 3A46 in the bioactivation ofaflatoxin B1. Biochemical Pharmacology 2018, 156:177-185.

  7. XianqingTang, Peiqiang Mu, JunWu,Jun Jiang, Caihui Zhang, Ming Zheng, Yiqun Deng*. CarbonylReduction of Mequindox by Chicken and Porcine Cytosol and ClonedCBR1. DrugMetabolism and Disposition2012, 40(4): 788-795.

  8. JunWu,Fen Du, Peng Zhang, Izhar Ahmed Khan, Jie Chen, Yi Liang*.Thermodynamics of the interaction of aluminum ions with DNA:Implications for the biological function of aluminum. Journal ofInorganic Biochemistry, 2005, 99: 1145-1154.