STAFF

Prof. Yiqun Deng

College of Life Sciences,

South China Agricultural University,

Guangzhou, Guangdong 510642, China

Tel: +86-20-38604967 (O)

E-mail: yqdeng@scau.edu.cn

Education

  • Ph.D., Biochemistry and Molecular Biology.

Sun Yat-sen University, China, 2002.

  • M.S., Biochemistry and Molecular Biology.

Zhongshan University of Medical Sciences, China, 1999.

  • B.S.Me, Clinical Medicine.

Wannan Medical College, China, 1996.

Professional Biography

  • 2007.12-present, Professor, College of Life Sciences, South China Agricultural University, China

  • 2007.7-2007.12, Instructor of Biochemistry, Weill Medical College of Cornell University, USA.

  • 2002.9-2007.6, Postdoctoral Associate, Department of Biochemistry, Weill Medical College of Cornell University, USA.

  • 2000.8-2002.2, Visiting Scholar, Department of Biochemistry, Hong Kong University of Science & Technology, Hong Kong, China.

Area of Expertise

  • The cytotoxicity of mycotoxins in animals.

  • The molecular mechanisms of metabolism for xenobiotics, especially mycotoxins.

  • The function, expression and regulation of key metabolic enzymes in animals, e.g.  Cytochrome P450.

Selected Publications

1.     Shulin Tang,   Yurong Zhao, Xirong He, Jiahui Zhu, Shuang Chen,Jikai Wen *, Yiqun   Deng*Identification of NOVA family proteins as   novel β-catenin RNA-binding proteins that promote epithelial-mesenchymal   transition. RNA Biology. 2020 Mar; 17(6): 881-891.

2.      Shulin Tang, Shuang Chen, Boyan Huang, Jun   Jiang, Jikai Wen, Yiqun Deng*. Deoxynivalenol   induces inhibition of cell proliferation via the Wnt/beta-catenin signaling   pathway. Biochemical Pharmacology. 2019 Aug;   166:12-22. (F1000★★)

3.      Haoran Jiang, Jun Wu, Feiyong Zhang, Jikai Wen,   Jun Jiang, Yiqun Deng*.   The critical role of porcine cytochrome P450 3A46 in the bioactivation   of aflatoxin B1. Biochemical Pharmacology.   2018 Oct; 156: 177-185.

4.      Xiaoming Li, Peiqiang Mu, Han Qiao, Jikai   Wen, Yiqun Deng*.   JNK-AKT-NF-κB controls P-glycoprotein expression to attenuate the cytotoxicity   of deoxynivalenol in mammalian cells.  Biochemical Pharmacology. 2018   Oct; 156: 120-134.

5.      Jun Jiang,  Shulin Tang, Jianhong Xia,   Jikai Wen, Shuang Chen, Xiaodong Shu, Michael S. Y.  Huen, Yiqun   Deng*. C9orf140, a novel Axin1-interacting protein, mediates the   negative feedback loop of Wnt/β-catenin signaling. Oncogene.   2018 May; 37(22): 2992-3005.

6.      Xin Liu, Jikai Wen, Ruohong Chen, Tingting Zhang, Jun   Jiang, Yiqun Deng*. T-2 toxin induces the   expression of porcine CYP3A22 via the upregulation of the transcription factor,   NF-Y. Biochimica et Biophysica Acta-General Subjects. 2016   Oct; 1860(10): 2191-2201.

7.      Qi Yang, Shulin Tang, Linfeng Dong, Qingmei Chen, Xin Liu, Jun   Jiang, Yiqun Deng*. Transcriptional regulation of   chicken cytochrome P450 2D49 (CYP2D49) basal expression by   CCAAT/enhancer-binding protein α (C/EBPα) and hepatocyte nuclear factor 4α   (HNF4α). FEBS Journal.2014 Mar; 281(5):  1379-1392.

8.      Jun Wu, Weiying Xu,  Caihui Zhang, Qing Chang, Xianqing   Tang, Kangbai Li, Yiqun Deng*.  Trp266   determines the binding specificity of a porcine aflatoxin B1 aldehyde   reductase for aflatoxin B1-dialdehyde.  Biochemical   Pharmacology2013 Nov; 86(9):  1357-1365.

9.      Shirley M.H. Sy#, Jun Jiang#,   Wai Sum O, Yiqun Deng*, Michael S.Y. Huen*.   The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand   breaks. Nucleic Acids Research. 2013   Oct; 41(18):  8572-8580.(#co-first    author)

10.    Jianshe Wang#, Jun Jiang#,   Hongxia Zhang, Junping Wang, Hua Cai, Cheng Li, Kangbai Li, Jing Liu,   Xuejiang  Guo, Guangxun Zou, Dazhi Wang, Yiqun Deng*,   Jiayin Dai*. Integrated transcriptional and proteomic analysis with in vitro   biochemical assay reveal the important role of CYP3A46 in T-2 toxin   hydroxylation in porcine primary hepatocytes. Molecular & Cellular   Proteomics. 2011 Sep; 10(9):    M111.008748. (#co-first  author)