STAFF

Prof. Jikai Wen

College of Life Sciences,
South China Agricultural University,

Guangzhou, Guangdong 510642, China
Office Tel: +86-20-85201331 (O)
E-mail: jkwen@scau.edu.cn
Skype: feiyewen2008


Education

  • Ph.D. (Molecular Cell Biology)

The University of Birmingham, UK, 2005-2009

  • M. Res. (Biochemistry and Molecular Biology)

Wuhan Institute of Virology, Chinese Academy of Sciences, 1999-2002

  • B. Sc. (Biotechnology)

Hubei University, China, 1995-1999


Professional Biography

Dr. Jikai Wen worked as research associate in Wuhan Institute of Virology, Chinese Academy of Sciences from 2003 to 2005, and as postdoctoral fellow in the University of Birmingham from 2009 to 2013 in UK, and enrolled as a professor in the SCAU in early 2014. He has severed as the head of the Department of Biochemistry and Molecular Biology, College of Life Sciences, SCAU since 2016 and associated director of Guangdong provincial key laboratory of Protein Function and Regulation in Agricultural Organisms since 2018.

Prof. Wen’s lab focuses on the toxicosis and detoxification of mycotoxins such as AFB1, DON and T-2 toxins in animals, especially the molecular explanations for mycotoxicosis of trichothecenes, catalysis mechanisms for biotransformation of microbial toxins and related applications.


Area of Expertise

Gene expression regulation, Signal transduction, Toxicosis, Mycotoxins, Enzyme engineering, Metabolism and Biotransformation



Selected Publications


  1. Ruqin Lin, Yu Sun, Peiqiang Mu, Ting Zheng, Haibin Mu, Fengru Deng, Yiqun Deng*, and Jikai Wen*. Lactobacillus rhamnosus GG supplementation modulates the gut microbiota to promote butyrate production, protecting against deoxynivalenol exposure in nude mice. Biochemical Pharmacology. 2020 May; 175, 113868.

  2. Shulin Tang#, Yurong Zhao#, Xirong He, Jiahui Zhu, Shuang Chen, Jikai Wen*, and Yiqun Deng*. Identification of NOVA family proteins as novel beta-catenin RNA-binding proteins that promote epithelial-mesenchymal transition. RNA Biology. 2020 Jun;17(6):881-891.

  3. Zhangsheng Hu#, Yu Sun#, Jiongjie Chen, Yurong Zhao, Han Qiao, Ruohong Chen, Xianhui Wen, Yiqun Deng*, and Jikai Wen*, Deoxynivalenol globally affects the selection of 3' splice sites in human cells by suppressing the splicing factors, U2AF1 and SF1. RNA Biology. 2020 Apr;17(4):584-595.

  4. Wenchu Ye, Ruohong Chen, Xiaoxuan Chen, Boyan Huang, Ruqin Lin, Xuan Xie, Jiongjie Chen, Jun Jiang, Yiqun Deng, and Jikai Wen*. AhR regulates the expression of human cytochrome P450 1A1 (CYP1A1) by recruiting Sp1. FEBS J. 2019 Jun 14; 286 (21), 4215-4231.

  5. Wenchu Ye, Ruqin Lin, Xiaoxuan Chen, Jiongjie Chen, Ruohong Chen, Xuan Xie, Yiqun Deng, and Jikai Wen*. T-2 toxin upregulates the expression of human cytochrome P450 1A1 (CYP1A1) by enhancing NRF1 and Sp1 interaction. Toxicol Lett.2019 Oct 15; 315, 77-86.

  6. Xuan Xie#, Jun Jiang, Wenchu Ye, Ruohong Chen, Yiqun Deng*, and Jikai Wen*. Sp1, Instead of AhR, Regulates the Basal Transcription of Porcine CYP1A1 at the Proximal Promoter. Front. Pharmacol. 2018 Aug 17; 9:927.

  7. Khalid Al-Jubran #, Jikai Wen #, Akilu Abdullahi#, Subhendu Roy Chaudhury, Min Li, Preethi Ramanathan, Annunziata Matina, Sandip De, Kim Piechocki, Kushal Nivriti Rugjee, and Saverio Brogna. Visualization of the joining of ribosomal subunits reveals the presence of 80S ribosomes in the nucleus. RNA. 2013 Dec; 19, 1669-1683.

  8. Jikai Wen, and Saverio Brogna. Splicing-dependent NMD does not require the EJC in Schizosaccharomyces pombe. Embo Journal. 2010 May 5;29, 1537-1551.

  9. Saverio Brogna, S., and Jikai Wen. Nonsense-mediated mRNA decay (NMD) mechanisms. Nature Structural & Molecular Biology. 2009 Feb; 16, 107-113.

  10. Jikai Wen#, Xian-en Zhang, Zhe Cheng, Hong Liu, Yafeng Zhou, Zhiping Zhang, Jihong Yang, and Jiaoyu Deng. A visual DNA chip for simultaneous detection of hepatitis B virus, hepatitis C virus and human immunodeficiency virus type-1. Biosens Bioelectron 2004 Feb 15;19, 685-92.