| 教授 生物化学系 硕士生导师 Email：jiangjun@scau.edu.cn |
个人简介
蒋珺，已发表SCI论文57篇，其中以第一作者或通讯作者（含同等贡献）在Nucleic Acids Research，Oncogene，Molecular & Cellular Proteomics，Archives of Toxicology，Journal of Agricultural and Food Chemistry等国际知名期刊发表SCI论文19篇；主持国家重点研发项目子课题、国家自然科学基金青年项目、广东省自然科学基金面上项目等课题10余项；以学术骨干/核心成员参与973计划子课题、NSFC-广东省联合基金重点项目、广东省自然科学基金研究团队、粤港真菌毒素生物防控团队等多项重点项目；入选广东省高等学校优秀青年教师培养计划、广州市珠江科技新星等人才项目；作为第二完成人获得2021年度第十二届大北农科技奖创新奖；担任中国生物化学与分子生物学会农业分会青年委员会副主任，广东省生物化学与分子生物学学会理事以及Journal of Agricultural and Food Chemistry, Chemical Research in Toxicology, Environmental Pollution,Chemosphere, Toxicology等知名期刊审稿人。
学习经历
1.2004/09-2009/07，中国科学院水生生物研究所，博士，导师：桂建芳院士
2.2000/09-2004/07，华中师范大学，生命科学学院，学士
工作经历
1.2022/12至今，华南农业大学，生命科学学院，教授
2.2019/09-2020/06，美国加州大学欧文分校，访问学者
3.2011/07-2022/11，华南农业大学，生命科学学院，副研究员
4.2011/04-2011/10，香港大学，李嘉诚医学院，高级研究助理
5.2009/07-2011/07，华南农业大学，生命科学学院，博士后，合作导师：邓诣群教授
研究方向
1. 畜禽霉菌毒素中毒病的发生发展机制与防控
2. 参与霉菌毒素代谢关键酶的功能、结构与调控
3. 细胞周期调控与肿瘤发生
发表论文（*通讯作者，#第一作者）
2025年
1. Wandi Bu#, Xinyao Wu#, Zhihang Zhong, Yaping Fang, Shuang Chen, Jun Jiang*, Yiqun Deng*. Immunotoxicity and effects of gut microbiota in chicks exposed to low doses of deoxynivalenol and 15-acetyl-deoxynivalenol. Toxicology and Applied Pharmacology. 2025 Sep 15:505:117568.
2. Wandi Bu#, Xinyao Wu#, Zhihang Zhong, Yuekai Li, Yaping Fang, Shuang Chen, Zige Wang,Ying Hong, Feiyang Dai, Yan Wang, Jun Jiang*, Yiqun Deng*. Epmedin C Alleviates Deoxynivalenol-Induced Immunotoxicity by Inhibiting Caspase‑1 Activation in Chicken Macrophages. Journal of Agricultural and Food Chemistry. 2025 Sep 17;73(37):23617-23632.
3. Tianqing Jiang, Luyu Deng, Ruqin Lin, Jun Jiang, Jian Zeng, Jikai Wen, Yiqun Deng. New insights into the mechanism of T-2 toxin cytotoxicity: stress granules inhibit the mTORC2/AKT signaling pathway, FOOD BIOSCIENCE, 2025, 68: 106806.
4. Yuting Wu, Ruqin Lin, Qianqian Yuan, Yu Sun, Yiwen Yuan, Tianqing Jiang, Jun Jiang, Peiqiang Mu, Jikai Wen, Yiqun Deng. Mechanistic insights into deoxynivalenol-Induced hepatic cholestasis via IRE1α/HNF1α/FXR signaling dysregulation in mice. Ecotoxicology and Environmental Safety. 2025 Aug:301:118489.
5. Ziming Huang, Miao Li, Zhiqin He, Xiliang Yan, Yinbao Wu, Peiqiang Mu, Jun Jiang, Xu Wang, Yan Wang. Rosemary Extract Reduces Odor in Cats Through Nitrogen and Sulfur Metabolism by Gut Microbiota-Host Co-Modulation. Animals (Basel). 2025 Jul 16;15(14):2101.
6. Xiaoying Jian, Duo Zheng, Shengping Pang, Peiqiang Mu, Jun Jiang, Xu Wang, Xiliang Yan, Yinbao Wu, Yan Wang. Gut Microbiota-A Powerful Tool for Improving Pig Welfare by Influencing Behavior Through the Gut-Brain Axis. Animals (Basel). 2025 Jun 26;15(13):1886.
7. Qiang Xu, Ruqin Lin, Tianqing Jiang, Luyu Deng, Yuting Wu, Yuan, Qianqian Yuan, Xueying Qi, Peiqiang Mu, Jun Jiang, Yiqun Deng, Jikai Wen. Enhanced SIRT1-TFEB Interaction Promotes Lysosome Biogenesis and Autophagy by Reducing TFEB Acetylation: Revealing the Enterotoxicity Disparity of Deoxynivalenol and T-2 Toxin. Journal of Agricultural and Food Chemistry. 2025 May 28;73(21):12993-13005.
8. Fengru Deng#, Chuying Yao#, Linyu Ke, Meichan Chen, Mi Huang, Jikai Wen, Qingmei Chen, Jun Jiang, Yiqun Deng*. Emerging threat to antibiotic resistance: Impact of mycotoxin deoxynivalenol on gut microbiota and clonal expansion of extensively drug-resistant enterococci. Environment International, 2025,197:109353.
2024年
1. Zige Wang, Qiang Huang, Feiyong Zhang, Jiajun Wu, Lingling Wang, Yu Sun, Yiqun Deng*, Jun Jiang*, The key role of porcine cytochrome P450 2A19 in the bioactivation of aflatoxin B1 in the liver. Journal of Agricultural and Food Chemistry. 2024 Jan 31;72(4):2334-2346.
2. Jianhong Xia#, Haiyun Wang#, Zhihang Zhong, Jun Jiang*, Inhibition of PIKfyve Leads to Lysosomal Disorders via Dysregulation of mTOR Signaling. Cells. 2024, 13, 953.
3. Lingling Wang, Zifeng Deng, Jieying Huang, Tingyuan Li, Jun Jiang, Wence Wang, Yu Sun, Yiqun Deng*. Zearalenone-induced hepatointestinal toxicity in laying hens: unveiling the role of gut microbiota and fecal metabolites. Poultry Science, 2024 November;103(11):1-14.
4. XingSheng Sun, Lin Ruqin, Xinxia Lu, Zhikai Wu, Xueying Qi, Tianqing Jiang, Jun Jiang, Peiqiang Mu, Qingmei Chen, Jikai Wen* & Yiqun Deng*. UPF3B modulates endoplasmic reticulum stress through interaction with inositol-requiring enzyme-1α. Cell Death & Disease, 2024 August 13;15:587.
2023年
1. Jiahui Zhu, Guihong Li, Qiang Huang, Jikai Wen, Yiqun Deng*, Jun Jiang*. TET3-mediated DNA demethylation and chromatin remodeling regulate T-2 toxin-induced human CYP1A1 expression and cytotoxicity in HepG2 cells. Biochemical Pharmacology. 2023 May; 211:115506.
2. Caizhu Wang#, Ruqin Lin#, Xueying Qi, Qiang Xu, Xingsheng Sun, Yurong Zhao, Tianqing Jiang, Jun Jiang, Yu Sun, Yiqun Deng*, Jikai Wen*. Alternative glucose uptake mediated by β-catenin/RSK1 axis under stress stimuli in mammalian cells. Biochemical pharmacology. 2023, Aug; 214, 115645.
3. Tianqing Jiang, Xueying Qi, Ruqin Lin, Jun Jiang, Jikai Wen*, Yiqun Deng*. T-2 toxin and deoxynivalenol (DON) exert distinct effects on stress granule formation depending on altered activity of SIRT1. Ecotoxicology and Environmental Safety. 2023 Jul 1; 259:115028.
4. Danyang Li, Guoqiang Liang, Peiqiang Mu, Jinquan Lin, Jiarun Huang, Chongwen Guo, Yang Li, Ruqin Lin, Jun Jiang, Jun Wu, Yiqun Deng*, Jikai Wen*. Improvement of catalytic activity of sorbose dehydrogenase for deoxynivalenol degradation by rational design. Food Chemistry. 2023 Oct 15; 423:136274.
其他代表性论文
1. Shirley M.H. Sy#, Jun Jiang#, Wai Sum O, Yiqun Deng*, Michael S.Y. Huen*. The Ubiquitin Specific Protease USP34 Promotes Ubiquitin Signaling at DNA Double-Strand Breaks. Nucleic Acids Research. 2013 Oct; 41(18): 8572-8580.
2. Jun Jiang#, Shulin Tang#, Jianhong Xia, Jikai Wen, Shuang Chen, Xiaodong Shu, Michael S. Y. Huen, Yiqun Deng*. C9orf140, a novel Axin1-interacting protein, mediates the negative feedback loop of Wnt/β-catenin signaling. Oncogene. 2018 May; 37: 2992-3005.
3. Jianshe Wang#, Jun Jiang#, Hongxia Zhang, Junping Wang, Hua Cai, Cheng Li, Kangbai Li, Jing Liu, Xuejiang Guo, Guangxun Zou, Dazhi Wang, Yiqun Deng*, Jiayin Dai*.Integrated transcriptional and proteomic analysis with in vitro biochemical assay reveal the important role of CYP3A46 in T-2 toxin hydroxylation in porcine primary hepatocytes. Molecular & Cellular Proteomics.2011 Sep; 10(9): M111.008748, 1-18.
4. Shirley M.-H. Sy#, Jun Jiang#, Sui-sui Dong, Gabriel Tsz-Mei Lok, Jun Wu, Hua Cai, Enoch S.L. Yeung, Jun Huang, Junjie Chen, Yiqun Deng*, Michael S.Y. Huen*. Critical roles of ring finger protein RNF8 in replication stress responses. Journal of Biological Chemistry. 2011 Jun 24; 286(25): 22355-22361.
主持与参加的科研项目
1. 国家重点研发子课题，2023，主持
2. 广东省自然科学基金面上项目，2023，主持
3. 国家自然科学基金联合基金，2024，参与
4. 区域联合基金-粤港澳研究团队项目，2022，参与
入选的人才基金项目
1.广州市科技计划项目珠江科技新星专项，2016
2.广东省高等学校优秀青年教师培养计划，2015
3.广东省高等学校“千百十人才培养工程”第八批校级培养对象，2014
授权发明专利
1.文继开；陈庆梅；张艳；邓诣群；吴骏；蒋珺；胡泰斗；胡章盛；一种基于人铁蛋白的纳米酶及其制备方法，2022.04.08，中国，ZL201810470199.2.
2.邓诣群；汪玲玲；蒋珺；吴骏；母培强；邓凤如；大肠杆菌在降解代谢黄曲霉毒素B1方面的应用，2020-08-07，中国，ZL201810316911.3.
3.邓诣群；汪玲玲；蒋珺；吴骏；母培强；邓凤如；一株高效降解黄曲霉毒素B1的大肠杆菌CG1061，2020-08-07，中国，ZL201810317744.4.
学术兼职
(1) 中国生物化学与分子生物学会农业分会青年委员会副主任
(2) 广东省生物化学与分子生物学学会青年委员会常务委员
(3) 广东省生物化学与分子生物学学会 理事
(4) 广东省生物物理学会常务理事
学术奖励
1.蒋珺(2/10); 饲料中常见霉菌毒素的分子毒理与生物防控, 大北农科技奖奖励委员会, 其他, 其他, 2021(邓诣群; 蒋珺; 文继开; 母培强; 汪玲玲; 吴骏; 林如琴; 陈庆梅; 邓凤如; 孙峪) (科研奖励)
