母培强:副研究员  性别: 男

    所属单位:生物化学系

 

    Email:mpeiqiang@scau.edu.cn

  


工作经历

1. 2018/01-今,华南农业大学,生命科学学院生化与分子生物学系,副研究员;

2. 2015/05-今,华南农业大学,生命科学学院生化与分子生物学系,青年副教授;

3. 2014/07-2017/12,华南农业大学,生命科学学院生化与分子生物学系,助理研究员;

4. 2013/10-2014/3,Johns Hopkins University (USA), Department of Biology, Visiting Scholar

5. 2011/08-2014/06,华南农业大学,生命科学学院生化与分子生物学系,博士后。合作导师:邓诣群。

学习经历
学位学历学科门类专业毕业学校类型入学时间毕业时间
博士

博士

研究生

理学
遗传学
中山大学
全日制2006-092011-07
学士大学本科
农学
蚕学
华南农业大学
全日制2002-092006-07
研究兴趣

真菌毒素的分子毒理机制:组蛋白修饰调控等

主持科研项目

1. 广东省自然科学基金,2019A1515011519,基于细胞周期阻滞的呕吐毒素致猪肝毒性的分子机制研究,2019/10/-2022/10,在研,主持;

2.广州市科技计划科学研究专项,201607010257,临床分离的猪沙门氏菌多重耐药机制研究, 2016/04-2019/03,已结题,主持;

3. 国家自然科学基金青年基金,31402250,多重耐药猪沙门氏菌耐药机制及抑制剂研究, 2015/01-2017/01,在研,主持;

4. 广东省自然科学基金博士启动项目, S2012040007589,DON毒素生物脱毒关键酶的筛选鉴定, 2012/10-2014/10,已结题,主持;

5. 中国博士后科学基金面上项目,2012M511577,鸡肠道中DON毒素脱环氧代谢微生物及关键酶的筛选鉴定, 2012/05-2014/05,已结题,主持。

发表论文

[1] Haibin Mu#, Peiqiang Mu#,  Wenya Zhu#, Boyan Huang, Hui Li, Liping Yuan, Yiqun Deng,Low doses of deoxynivalenol inhibit the cell migration mediated by H3K27me3-targeted downregulation of TEM8 expression. Biochemical pharmacology, 2020. doi:10.1016/j.bcp.2020.113897
[2] Xiaojuan Gao#, Peiqiang Mu#, Xunhua Zhu, Xiaoxuan Chen, Shulin Tang,Yuting Wu, Xiang Miao, Xiaohan Wang, Jikai Wen and Yiqun Deng,Dual Function of a Novel Bacterium, Slackia sp. D-G6: Detoxifying Deoxynivalenol and Producing the Natural Estrogen Analogue, Equol. Toxins. 2020. 12(2). pii: E85. doi: 10.3390/toxins12020085.
[3] Boyan Huang#, Peiqiang Mu#, Xiaoxuan Chen, Shulin Tang, Wenchu Ye, Wenya Zhu, and Yiqun Deng, Aflatoxin B-1 induces S phase arrest by upregulating the expression of p21 via MYC, PLK1 and PLD1. Biochemical Pharmacology, 2019. 166: 108-119.

[4] Liping Yuan#, Peiqiang Mu#, Boyan Huang, Hui Li, Haibin Mu, and Yiqun Deng, EGR1 is essential for deoxynivalenol-induced G2/M cell cycle arrest in HepG2 cells via the ATF3 Delta Zip2a/2b-EGR1-p21 pathway. Toxicology Letters, 2018. 299: 95-103.
[5] Lingling Wang, Jun Wu, Zhiwen Liu, Yutao Shi, Jinqiu Liu, Xiaofan Xu, Shuxian Hao, Peiqiang Mu, Fengru Deng, and Yiqun Deng, Aflatoxin B-1 Degradation and Detoxification by Escherichia coli CG1061 Isolated From Chicken Cecum. Frontiers in Pharmacology, 2019. 9: 5148
[6] Xiaoming Li, Peiqiang Mu, Han Qiao, Jikai Wen, and Yiqun Deng, JNK-AKT-NF-kappa B controls P-glycoprotein expression to attenuate the cytotoxicity of deoxynivalenol in mammalian cells. Biochemical Pharmacology, 2018. 156: 120-134. (5Yr-IF:4.637)
[7] XiaojuanGao#, Peiqiang Mu#, Jikai Wen, Yu Sun, Qingmei Chen, Yiqun Deng*.Detoxification of trichothecene mycotoxins by a novel bacterium, Eggerthellasp. DII-9. Food and chemical toxicology,2018.112:310-319
[8] ShijieMa, Yurong Zhao, Jianwei Sun, Peiqiang Mu, Yiqun Deng*. miR449a/SIRT1/PGC-1α is necessaryfor mitochondrial biogenesis induced by T-2 toxinFrontiers in Pharmacology,2018.8:954
[9] XiaomingLi, Peiqiang Mu, Jikai Wen, YiqunDeng. Carrier-Mediated and Energy-Dependent Uptake and Efflux of Deoxynivalenolin Mammalian Cells. Scientific Reports 2017; 7(1): 5889.
[10] JikaiWen#, Peiqiang Mu#, Yiqun Deng*. Mycotoxins:cytotoxicity and biotransformation in animal cells. Toxicology Research, 2016.5(2):377-387
[11] PeiqiangMu, Ming Zheng, Ming Xu, Yuan MingZheng, Xianqing Tang, Yufan Wang, Kaixin Wu, Qingmei Cheng, Lijuan Wang, YiqunDeng*. N-oxide Reduction of Quinoxaline-1, 4-dioxides Catalyzed by PorcineAldehyde Oxidase SsAOX1. Drug Metab Dispos. 2014,42:511–15. 2014.
[12] PeiqiangMu, Ming Xu, Kaixin Wu, Jun Wu,Jun Jiang, Qingmei Chen, Lijuan Wang, Xianqing Tang, Yiqun Deng*. Proteomicchanges in chicken primary hepatocytes exposed to T-2 toxin are associated withoxidative stress and mitochondrial disorder. Proteomics. 2013,13: 3175–88.
[13] PeiqiangMu, Dongru Feng, Jianbing Su, YangZhang, Jinran Dai, Honglei Jin, Bing Liu, Yanming He, Kangbiao Qi, HongbingWang, Jinfa Wang*. Cu2+ triggers reversible aggregation of adisordered His-rich dehydrin MpDhn12 from Musa paradisiaca.J Biochem . 2011, 150:491-499.
[14] XianqingTang, Peiqiang Mu, Jun Wu, Jun Jiang, Caihui Zhang, Ming Zheng, YiqunDeng*. Carbonyl Reduction of Mequindox by Chicken and Porcine Cytosol andCloned CBR1. Drug Metab Dispos. 40(4): 788-95. 2012.
[15]Jun Wu,Ruohong Chen, Caihui Zhang, Kangbai Li, Weiying Xu, Lijuan Wang, Qingmei Chen, Peiqiang Mu, Jun Jiang, Jikai Wen, andYiqun Deng, Bioactivation and Regioselectivity of Pig Cytochrome P450 3A29towards Aflatoxin B1. Toxins. 8(9), 267;2016.
[16] BingLiu, Jieqiong Fan, Yang Zhang, Peiqiang Mu, Peng Wang, Jianbing Su,Huihuang Lai, Dongru Feng, Jinfa Wang, Hongbing Wang*. OsPFA-DSP1, a riceprotein tyrosine phosphatase, negatively regulates drought stress responses intransgenic tobacco and rice plants. Plant Cell Rep. 31(6): 1021-32. 2012.
[17] Jin Liu,Man Ouyang, Jun Jiang, Peiqiang Mu, Jun Wu, Qi Yang, Caihui Zhang,Weiyin Xu, Lijuan Wang, Micheal S.Y. Huen, Yiqun Deng*. Mequindoxinduced cellular DNA damage via generation of reactive oxygen species. MutatRes 741: 70-75.2012.
[18] BingLiu, Dongru Feng, Bipei Zhang, Peiqiang Mu, Yang Zhang, Yanming He,Kangbiao Qi, Jinfa Wang, Hongbing Wang*. Musa paradisica RCIcomplements AtRCI and confers Na(+) tolerance and K(+) sensitivity in Arabidopsis. Plant Sci 184: 102-111.2012. 

发明专利

1. 邓诣群、母培强、高小娟、陈庆梅、文继开,伊格尔兹氏菌Eggerthella sp. DII -9在降解呕吐毒素中的应用,2018.01.19,中国,ZL201610785036.4

2. 邓诣群、高小娟、母培强、陈庆梅、文继开,一株高效降解呕吐毒素的伊格尔兹氏菌Eggerthella sp. DII -92017.07.11,中国,ZL201610785205.4

3. 邓诣群、郑鸣、唐先青、母培强,一种具有重要药物代谢活性的猪醛氧化酶(SsAOX1)的基因序列及其应用,2015. 04.08,中国,ZL201210385945.0   

学术会议报告

1. Peiqiang Mu, The Dual role of mitochondrion in T-2 toxin response, 12th Conference of the Asian Society of Mitochondrial Research and Medicine (ASMRM) and The 6th Conference of Chinese Society of Mitochondrial Research and Medicine (Chinese-Mit), Hangzhou, China, 13 - 15 November 2014

2. 母培强,霉菌毒素T-2的毒性机理研究,动物生理生化学会第13次学术年会,20148月,沈阳,中国。