王应祥

发布者:生命科学学院发布时间:2022-04-01浏览次数:4472

   

    华南农业大学生命科学学院教授

    岭南现代农业科学与技术广东省实验室 研究员

    生命科学学院 院长

    电子邮箱yxwang@scau.edu.cn




研究兴趣

1.大豆适应热带亚热带的分子遗传基础和新种质创制

2.植物生殖发育的遗传和表观遗传调控机制


教育经历

1998-2007    华南农业大学获农学学士和博士学位


工作经历

2007-2011    华南农业大学和复旦大学 博士后

2004-20052013-2014    宾州州立大学 访问学者

2011-2015    复旦大学生命科学学院 副研究员

2015-2020    复旦大学生命科学学院 研究员

2020至今     复旦大学 特聘教授

2022至今     华南农业大学生命科学学院 教授

2022至今     岭南现代农业科学与技术广东省实验室 研究员


社会兼职

Guest Associate Editor in PLOS Genetics

Associate Editor in Reproduction and Breeding

中国遗传学会青年学术委员会

中国植物学会植物细胞生物学专业委员会委员

中国植物学会植物结构与生殖生物学专业委员会委员

中国植物生理与植物分子生物学学会细胞与发育生物学专业委员会委员

中国细胞生物学学会植物器官发生分会委员


研究领域和成果 

    减数分裂直接影响动物生殖和作物育性与产量。申请人一直致力于以植物为材料,从事减数分裂的分子机制研究,取得的主要成果包括:1)揭示了4DNA复制因子在减数分裂重组中的功能,提出包括DNA后随链合成的重组模型;2)发现了重组在染色体间的分布规律及调控机制;3)阐明了减数分裂特异染色体浓缩进程的表观遗传调控机制。迄今在Annual Review of  Plant BiologyNature PlantsPlant CellPNAS等杂志共发表SCI论文和综述54篇。

获上海市青年科技启明星计划、教育部国家重点人才工程(国内)、国家基金委“杰出青年”基金;入选复旦大学“卓学”和“卓识” 人才计划;复星医药奖教金一等奖(3次)和特等奖(1次);复旦大学生科院院长奖和遗传与发育协同创新中心年度十大科技进展等。


代表性论文和论著

1、Wang C#, Huang J, Li Y, Zhang J, He C, Li T, Jiang DH, Dong AW, Ma H*, Copenhaver GP*. Wang YX*.DNA Polymerase Epsilon Binds Histone H3.1-H4 and Recruits MORC1 to Mediate Meiotic Heterochromatin Condensation. PNAS, 2022, 119(43): e2213540119.

2、Wang C, Huang J, Zhang J, You Y, Copenhaver GP. You CJ*, Wang YX*. DNA polymerase epsilon interacts with SUVH2/9 to repress the expression of genes associated with meiotic DSB hotspot in Arabidopsis, PNAS, 2022, 119(43): e2208441119.

3、Xian P, Cai Z, Jiang B, Xia Q, Cheng Y, Yang Y, Zhou Q, Lian T, Ma Q, Wang Y*, Ge L*, Nian H*. GmRmd1 encodes a TIR-NBS-BSP protein and confers resistance to powdery mildew in soybean. Plant Commun. 2022, Aug 10:100418. doi: 10.1016.

4、 He C#, Chen Z#, Zhao Y, Yu Y, Wang H, Wang C, Copenhaver GP, Qi J*, Wang YX*.Histone demethylase IBM1-mediated meiocyte gene expression ensures meiotic chromosome synapsis and recombination. PLoS Genet. 2022 18:e1010041.

5、Li X, Zhang J, Huang J, Xu J, Chen Z, Copenhaver GP, Wang YX*. Regulation of interference-sensitive crossover distribution ensures crossover assurance in Arabidopsis. PNAS. 2021 118:e2107543118.

6、Chen H#, He C#, Wang C#, Wang X, Ruan F, Yan J, Yin P, Wang YX*, Yan SP*. RAD51 supports DMC1 by inhibiting the SMC5/6 complex during meiosis. Plant Cell. 2021 Aug 31;33(8):2869-2882.

7、Li X, Yu MS, Bolaños-Villegas P, Zhang J, Ni DA, Ma H, Wang YX*. Fanconi Anemia Ortholog FANCM Regulates Meiotic Crossover Distribution in Plants. Plant Physiology, 2021, 186:344-360.

8、Fang XL, Han YP, Liu MS, Jiang JC, Li X, Lian QC, Xie XR, Huang Y, Ma QB, Nian H, Qi J, Yang CY*, Wang YX*. Modulation of Evening Complex Activity Enables North-to-South Adaptation of Soybean. SCIENCE CHINA Life Sciences, 2020, (Cover story) 中国科学生命科学专文点评

9、Wang J#, Yu CY#, Zhuang SB, Ye JY, Dai H, Wang HK, Huang JY, Cao XF, Ma JB*, Ma H*, Wang YX*. Cell-type-dependent histone demethylase specificity promotes meiotic chromosome condensation in Arabidopsis. Nature Plants, 2020, 10.1038/s41477-020-0697-0.

10、Wang HK#, Xu WY#, Sun YJ, Lian QC, Wang C, Yu CY, He CP, Wang J, Ma H, Copenhaver GP*, Wang YX*. The cohesin loader SCC2 contains a PHD finger that is required for meiosis in land plants. PLoS Genetics, 2020, doi.org/10.1371/journal.pgen.1008849.

11、Huang JY#, Wang C#, Li X, Fang XL, Huang N, Wang Y, Ma H, Wang YX*, Copenhaver GP*. Conservation and divergence in the meiocyte sRNAomes of Arabidopsis, soybean and cucumber. Plant Physiology, 2020, 82:301-317.

12、Xu RY#, Xu J#, Wang LD#, Niu BX, Copenhaver GP, Ma H, Zheng BL, Wang YX*. The Arabidopsis anaphase promoting complex/cyclosome subunit 8 is required for male meiosis. New Phytologist, 2019, 224(1):229-24.

13、1Huang JY#, Wang C#, Wang HF, Lu PL, Zheng BL, Ma H, Copenhaver GP, Wang YX*. Meiocyte-specific and AtSPO11-1-dependent small RNAs and their association with meiotic gene expression and recombination. Plant Cell, 2019, 31:1-21. In brief by the editor in the same issue.

14、Wang C#, Huang JY#, Zhang J, Wang HK, Han YP, Copenhaver GP, Ma H, Wang YX*. The Largest Subunit of DNA Polymerase Delta is Important for Normal Formation of Meiotic Type I Crossovers in Arabidopsis. Plant Physiology, 2019, 179: 446-459.

15、Xue M#, Wang J#, Jiang LG, Wolfe S, Pawlowskic WP*, Wang YX*, He Y* (2018) The number of meiotic double-strand breaks influences crossover distribution in Arabidopsis. Plant Cell, 2018, 30: 2628-2638,

16、Wang YX*, Copenhaver GP*. Meiotic Recombination: Mixing It Up in Plants. Annual Review Plant Biology. 2018, 69: 577-609

17、Su H#, Chen ZH#, Huang JY, Lin J, Copenhaver GP, Ma H, Wang YX*. Arabidopsis RAD51, RAD51C and XRCC3 proteins form a complex and facilitate RAD51 localization on chromosomes for meiotic recombination. PLoS Genetics, 2017, e1006827. doi: 10.1371

18、Wang J, Niu BX, Huang JY, Wang HK, Yang XH, Dong AW, Mackaroff C, Ma H, Wang YX*. Arabidopsis MMD1 Ensures the Progression of Male Meiotic Chromosome Condensation and Directly Regulates the Expression of Condensin Gene CAP-D3. Plant Cell. 2016, 28:1894-1909.

19、Niu BX#, Wang LD#, Zhang LS, Ren D, Ren R, Copenhaver GP, Ma H*, Wang YX*. The Arabidopsis CDC20.1 Gene is Required for Normal Meiotic Spindle Assembly and Chromosome Segregation. Plant Cell. 2015, 27:1-16.

20、Huang JY#, Cheng ZH#, Wang C, Hong Y, Su H, Wang H, Copenhaver GP, Ma H*, Wang YX*. Formation of interference-sensitive meiotic crossovers requires sufficient DNA leading strand elongation. PNAS, 2015, 112:12534-9.